What is HIPEC surgery?

HIPEC (Hyperthermic Intraperitoneal Chemotherapy) is a specialized procedure involving the perfusion of the abdominal cavity with a highly concentrated solution of chemotherapeutic drugs heated to a temperature of 42°C. The procedure, which takes about 90 minutes, is performed after surgically removing visible tumors within the abdominal cavity as part of cytoreductive surgery.

Benefits of HIPEC procedure

The doses of drugs administered via HIPEC are approximately 20 times higher than in conventional intravenous chemotherapy. This significantly improves the effectiveness of the treatment. As the treatment is localized rather than systemic, the toxic effects of the drugs are also minimized. So far, the combination of heated, highly concentrated chemotherapy alongside surgical mass resection is the most effective method for treating metastatic abdominal cancer.

According to numerous publications, the outcomes of HIPEC are significantly better than those of conventional chemotherapy or surgery alone.

Who is a candidate for HIPEC?

HIPEC is indicated for cases of metastatic abdominal cancer originating from primary gastrointestinal tract cancers, ovarian cancer, or mesothelioma. HIPEC is not suitable for all patients, but only in the following cases:

Metastases are limited to the abdominal cavity, with no spread to distant organs. This must be confirmed through PET-CT or chest/abdominal CT scans.
The patient’s functional status must be good, without other serious conditions (such as kidney or cardiovascular diseases).